The film follows two prisoners in the near future who are sentenced to a lifetime of hard labor on a distant planet. As things unravel, they become increasingly paranoid and start to lose a sense of who they are and their past lives.

Renowned oneirologist, Ambrose London, is requested to Arkham Asylum to study the strange case of split personality in patient James Fhelleps/Joe Slater.

影片时间线设定在1979年第一部《异形》与1986年的续集《异形2》之间，围绕一群年轻而勇敢的太空殖民者展开。讲述他们为逃离外星采矿殖民地的沉闷生活，在冒险探索一座废弃的太空站时，意外遭遇了宇宙中最可怕的生命体——异形。狭窄幽暗、危机四伏的空间站中，大逃杀的序幕已经被无情拉开，人类再次成为异形生物捕猎的目标。在无尽的黑暗与死亡威胁的笼罩之下，太空探险队员们能否在每一次心跳的瞬间，察觉到未知生物潜伏的丝丝寒意？在这场你死我活的追逐战中，他们将直面怎样的信任挑战和道德挣扎？当一个又一个同伴被残忍吞噬，求救无门的他们究竟能否在这场太空杀戮中寻得一线生机？